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Follow-up treatments are usually required to maintain the effect. For instance, hyaluronic acid fillers (Juvederm®, Restylane™ and Perlane®) last up to 12 months. Keep in mind that everyone’s skin is different, the timing of any additional wrinkle treatment will vary from person to person. When repeat treatments occur over time, either the interval between appointments becomes longer, or less product is required to achieve the same results, or more areas can be treated with the same amount of product.